scholarly journals Ultrastructure of acinic cell carcinoma of the parotid salivary gland

Cancer ◽  
1972 ◽  
Vol 29 (1) ◽  
pp. 235-244 ◽  
Author(s):  
Saul Kay ◽  
Peter F. Schatzki
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell ◽  
Parotid Salivary Gland

scholarly journals A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anthony C. Nichols ◽  
Michelle Chan-Seng-Yue ◽  
John Yoo ◽  
Sumit K. Agrawal ◽  
Maud H. W. Starmans ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Large Scale ◽  
Cellular Proliferation ◽  
Genetic Characterization ◽  
Distant Metastases ◽  
Acinic Cell Carcinoma ◽  
Nonsynonymous Mutation ◽  
Acinic Cell

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

2020 ◽  
Author(s):  
Yuichiro Hamamoto ◽  
Hiroshi Harada ◽  
Masaharu Kohara ◽  
Keiichiro Honma ◽  
Shin-ichi Nakatsuka ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Secretory Carcinoma ◽  
Acinic Cell

Acinic cell carcinoma arising in minor salivary gland of the upper lip

2017 ◽  
Vol 29 (4) ◽  
pp. 309-313
Author(s):  
Hiroaki Miyazaki ◽  
Takaaki Kamatani ◽  
Masahiro Nagasaki ◽  
Masakatsu Itose ◽  
Takashi Moriya ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Acinic Cell Carcinoma ◽  
Upper Lip ◽  
Acinic Cell
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